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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1008408Generated: November 2, 2026

Methanol → HCID 22667068, compound

https://huagongshe.com/reaction/1008408

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantBenzene, 1-isocyanato-2-methoxy-HCID 69695—
Reactant2-Chloro-4-((6,7-dimethoxyquinazolin-4-yl)oxy)anilineHCID 21889899—
SolventChloroformHCID 6212—
ProductHCID 22667068HCID 2266706854%

Reaction Steps

2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-aniline (50 mg) was dissolved in chloroform (5 ml), and 2-methoxyphenyl isocyanate (24 μl) was then added to the solution. The mixture was stirred at 60 C for one hr. Methanol was added to the reaction solution, and the mixture was purified by HPLC by development with chloroform/methanol to give 39 mg (yield 54%) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06797823B1
Source datasetuspto-grants-2004_09
ORD IDord-deb90bc0f5504f3ba2791383b79a4d5f
Source noteuspto-grants-2004_09