Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-Tolyl isocyanate | HCID 69194 | — |
| Reactant | 4-((6,7-Dimethoxy-4-quinazolinyl)oxy]-2-fluoroaniline | HCID 21890274 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 22667088 | HCID 22667088 | 24% |
Reaction Steps
4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-2-fluoro-aniline (50 mg) was dissolved in chloroform (3 ml) and o-toluyl isocyanate (30 μl) was then added to the solution. The mixture was stirred at 60° C. overnight. Methanol was added to the reaction solution, and the mixture was purified by HPLC by development with chloroform/methanol to give 17 mg (yield 24%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06797823B1 |
|---|
| Source dataset | uspto-grants-2004_09 |
|---|
| ORD ID | ord-0219f68caa37427c8df06418d3b71599 |
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| Source note | uspto-grants-2004_09 |
|---|
