HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1008415Generated: October 25, 2026
Methanol → N-{4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-2-fluorophenyl}-N'-(2-methoxyphenyl)urea
https://huagongshe.com/reaction/1008415
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Benzene, 1-isocyanato-2-methoxy- | HCID 69695 | — |
| Reactant | 4-((6,7-Dimethoxy-4-quinazolinyl)oxy]-2-fluoroaniline | HCID 21890274 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | N-{4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-2-fluorophenyl}-N'-(2-methoxyphenyl)urea | HCID 22667175 | 30% |
Reaction Steps
4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-2-fluoro-aniline (50 mg) was dissolved in chloroform (3 ml), and 2-methoxyphenyl isocyanate (32 μl) was then added to the solution. The mixture was stirred at 60° C. overnight. Methanol was added to the reaction solution, and the mixture was purified by HPLC by development with chloroform/methanol to give 22 mg (yield 30%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06797823B1 |
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| Source dataset | uspto-grants-2004_09 |
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| ORD ID | ord-4a64358cf0bd4ba69a26d78485ca4aa3 |
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| Source note | uspto-grants-2004_09 |
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