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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1008418Generated: October 31, 2026

2,4-Difluorophenyl isocyanate → HCID 22667142, compound

https://huagongshe.com/reaction/1008418

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-Difluorophenyl isocyanateHCID 593258—
ReactantHCID 22667239HCID 22667239—
SolventChloroformHCID 6212—
ProductHCID 22667142HCID 2266714279%

Reaction Steps

4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-3-methyl-aniline (50 mg) was dissolved in chloroform (3 ml), and 2,4-difluorophenyl isocyanate (23 μl) was then added to the solution. The mixture was heated under reflux overnight. The precipitated crystal was collected by filtration and was washed to give 59 mg (yield 79%) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06797823B1
Source datasetuspto-grants-2004_09
ORD IDord-3279ecb916ab4195b217b89f6cef781c
Source noteuspto-grants-2004_09