反应详情

温度

140 °C

A mixture of 10 g of 1b, 31 g of phenol and 4 g of KOH was heated at 140° C. for 2 hours. After cooling to room temperature aqueous 3N NaOH was added and the mixture was extracted with dichloromethane. The dichloromethane extract was washed with aqueous 2N NaOH, washed with water, dried (MgSO4) and concentrated to yield 12.2 g of 1c. 1H-NMR 200 MHz (CDCl3) δ: 7.1-7.6 (6H, m), 7.70 (1H, dd, J=9 Hz and J=2 Hz), 7.95-8.10 (2H, m), 8.31 (1H, d, J=9 Hz).

1. additionwas added
2. extractionthe mixture was extracted with dichloromethane
3. extractionThe dichloromethane extract
4. washwas washed with aqueous 2N NaOH
5. washwashed with water
6. dry with materialdried (MgSO4)
7. concentrationconcentrated