HRID1008487

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5951

(2S)-2-Amino-3-hydroxy-propanoic acid

C3H7NO3

HCID7125

2-Naphthalenesulfonyl chloride

C10H7ClO2S

结构：O=C(O)[C@H](CO)NS(=O)(=O)c1ccc2ccccc2c1

HCID14030411

未命名化合物

结构：CC(C)(C)OC(=O)NC(Cc1ccc2c(N)nccc2c1)C(=O)N1CCCCC1

HCID22665607

未命名化合物

结构：Cc1c(C)c(S(=O)(=O)NCC(=O)NC(Cc2ccc3c(N)nccc3c2)C(=O)N2CCCCC2)c(C)c2c1OC(C)(C)CC2.Cl

HCID22665631

未命名化合物

PRODUCTS

生成物

结构：Cl.Nc1nccc2cc(CC(NC(=O)[C@H](CO)NS(=O)(=O)c3ccc4ccccc4c3)C(=O)N3CCCCC3)ccc12

HCID69781330

未命名化合物

PROCEDURE

实验过程

The procedure described for 5c was used. Deprotection of 5a and coupling with (2S)-3-hydroxy-2-[(2-naphthalenyisulfonyl)amino]propanoic acid (prepared from L-serine and 2-naphthalenylsulfonylchloride using the procedure described for 5b) yielded 7. 1H-NMR 200 MHz (CD3OD) δ: 1.12-1.58 (6H, m), 2.57-2.69 (1H, m) 2.95-3.95 (8H, m), 4.9-5.1 (1H, m), 7.11-7.22 (1H, m), 7.43-8.16 (9H, m), 8.24-8.34 (1H, m), 8.41-8.45 (1H, m).

WORKUP

后处理

customyielded 7

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-44d0b00bd4054c32942da50141e4bd8d
来源数据集: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06797710B2
来源说明: uspto-grants-2004_09

反应 SMILES

Cl.[NH2:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([CH2:13][CH:14]([NH:23][C:24](=[O:45])[CH2:25][NH:26][S:27]([C:30]3[C:31]([CH3:44])=[C:32]([CH3:43])[C:33]4OC(C)(C)[CH2:36][CH2:35][C:34]=4[C:41]=3C)(=[O:29])=[O:28])[C:15](=[O:22])[N:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)=[CH:10][CH:11]=2)[CH:6]=[CH:5][N:4]=1.NC1C2C(=CC(CC(NC(=O)OC(C)(C)C)[C:59](=[O:66])N3CCCCC3)=CC=2)C=CN=1.OC[C@H](NS(C1C=CC2C(=CC=CC=2)C=1)(=O)=O)C(O)=O.N[C@H](C(O)=O)CO.C1C2C(=CC=CC=2)C=CC=1S([Cl:115])(=O)=O>>[ClH:115].[NH2:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([CH2:13][CH:14]([NH:23][C:24](=[O:45])[C@@H:25]([NH:26][S:27]([C:30]3[CH:31]=[CH:44][C:33]4[C:34](=[CH:35][CH:36]=[CH:43][CH:32]=4)[CH:41]=3)(=[O:29])=[O:28])[CH2:59][OH:66])[C:15](=[O:22])[N:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)=[CH:10][CH:11]=2)[CH:6]=[CH:5][N:4]=1