7-methoxynaphthalene-2-sulfonyl Chloride → HCID 69780337, compound

Participants

Reaction Steps

Using the procedure described for 11a, methyl ester 37i and compound 12a gave 3-(1-amino-7-isoquinolinyl)-2-[[(7-methoxy-2-naphthalenyl)sulfonyl)amino]propionic acid methyl ester. This ester was saponified and subsequently coupled with 4-methylpiperidine using the procedure described for 4 to give 37. 1H-NMR 200 MHz (CD3OD) δ: −0.20-0.77 (5H, m), 1.22-1.58 (3H, m), 1.73-3.20 (4H, m), 3.65-4.19 (2H, m), 3.93 (3H, s), 4.53-4.68 (1H, m), 7.00-7.06 (1H, m), 7.23-7.31 (2H, m), 7.43-7.51 (2H, m), 7.56-8.15 (6H, m).

Provenance & Evidence