反应详情

To a stirred solution of 100 mg of 3-nitrodibenzofuran in 1.7 mL of dichloromethane at −20° C. under a nitrogen atmosphere was added 0.44 mL chlorosulfonic acid in small portions. The reaction mixture was allowed to slowly warm to room temperature and stirred for 66 hours at room temperature. The reaction mixture was poured into ice-cold water, extracted four times with dichloromethane, dried (magnesium sulfate) and concentrated. Purification on silica gel (dichloromethane) yielded 129 mg of 50a: rf=0.73.

1. additionThe reaction mixture was poured into ice-cold water
2. extractionextracted four times with dichloromethane
3. dry with materialdried (magnesium sulfate)
4. concentrationconcentrated
5. customPurification on silica gel (dichloromethane)