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HRID1008506

反应详情

EQUATION

反应方程式

HRID 1008506 的结构方程式

REACTANTS

反应物

3
结构：CC(C)(C)OC(=O)NC(Cc1ccc2c(N)nccc2c1)C(=O)N1CCCCC1
HCID22665607

未命名化合物

结构：Cc1c(C)c(S(=O)(=O)NCC(=O)NC(Cc2ccc3c(N)nccc3c2)C(=O)N2CCCCC2)c(C)c2c1OC(C)(C)CC2.Cl
HCID22665631

未命名化合物

结构：COc1cc(C)c(S(=O)(=O)N[C@@H](CC(=O)N2CCOCC2)C(=O)O)c(C)c1C
HCID86758418

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(C)c(S(=O)(=O)N[C@@H](CC(=O)N2CCOCC2)C(=O)NC(Cc2ccc3c(N)nccc3c2)C(=O)N2CCCCC2)c(C)c1C.Cl
HCID86758416

未命名化合物

PROCEDURE

实验过程

The procedure described for 5c was used. Deprotection of 5a and coupling with 51a yielded after purification the title compound (79%) as a mixture of diastereomers (1:1). 1H-NMR 200 MHz (CD3OD) δ: 1.30-1.51 (6H, m), 2.14 (3H, s), 2.51 and 2.53 (3H, 2× s), 2.63 (3H, s), 2.31-3.62 (16H, m), 3.84 and 3.86 (3H, 2× s), 3.99-4.15 (1H, m), 5.08-5.21 (1H, m), 6.75 and 6.76 (1H, 2× s), 7.18-7.25 (1H, m), 7.52-7.81 (3H, m), 8.25-8.37 (1H, m).

WORKUP

后处理

  1. customyielded
  2. customafter purification the title compound (79%)
  3. additionas a mixture of diastereomers (1:1)