1-Octanesulfonyl chloride → Octane-1-sulfonic acid [1-(4-amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-amide

HRID 1008522Notes

Reaction equation

HRID 1008522 reaction equation
[CH2:1]([S:9](Cl)(=[O:11])=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[NH2:13][C:14]1[C:19]2[CH:20]=[C:21]([CH2:23][CH:24]([NH:34]S(C3C=CC(OC4CCOCC4)=CC=3)(=O)=O)[C:25]([N:27]3[CH2:32][CH2:31][CH:30]([CH3:33])[CH2:29][CH2:28]3)=[O:26])[S:22][C:18]=2[CH:17]=[CH:16][N:15]=1>>[NH2:13][C:14]1[C:19]2[CH:20]=[C:21]([CH2:23][CH:24]([NH:34][S:9]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])(=[O:11])=[O:10])[C:25]([N:27]3[CH2:28][CH2:29][CH:30]([CH3:33])[CH2:31][CH2:32]3)=[O:26])[S:22][C:18]=2[CH:17]=[CH:16][N:15]=1

Participants

3

Reactant 2

HCID 822611-Octanesulfonyl chlorideHCID 22665795N-[1-(4-Amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-4-(tetrahydropyran-4-yloxy)-benzenesulfonamide

Product 1

HCID 86758421Octane-1-sulfonic acid [1-(4-amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-amide

Procedure

This compound was prepared from 0.15 mL of octane sulfonyl chloride and 210 mg of 30a using the procedure described for 58c. Yield: 150 mg; m.p. 101-112° C., (+)-FAB-MS: 495 (MH+).

Sources & evidence

ORD record
ord-5a48b55f6cac4b2fb16c3a73a41544da
Source dataset
uspto-grants-2004_09
Patent number
US06797710B2

Reaction notes

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