HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-(Aminomethyl)isoquinolin-1-amine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[6-(aminomethyl)-1-isoquinolinyl]benzamide | HCID 22665809 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-(Aminomethyl)isoquinolin-1-amine hydrochloride | HCID 22665737 | — |
Reaction Steps
A solution of 5.8 g of N-[6-(aminomethyl)-1-isoquinolinyl]benzamide in 300 mL of 4N hydrochloric acid and 150 mL of acetic acid was refluxed for 6 hours. The reaction mixture was washed with diethylether to remove benzoic acid and the aqueous solution was concentrated under reduced pressure to give 3.0 g of the title compound. MS (m/e)=173.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06797710B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-09222e6db2384943b539e01540763c6e |
| Source note | uspto-grants-2004_09 |