1-Bromo-7-(4-fluoro-phenoxy)-4-hydroxy-isoquinoline-3-carboxylic acid butyl ester → 1-Cyano-7-(4-fluoro-phenoxy)-4-hydroxy-isoquinoline-3-carboxylic acid butyl ester
Reaction equation
[CH2:1]([CH2:2][CH2:3][CH3:4])[O:5][C:6](=[O:7])[c:8]1[n:9][c:10]([Br:27])[c:11]2[cH:12][c:13]([O:19][c:20]3[cH:21][cH:22][c:23]([F:26])[cH:24][cH:25]3)[cH:14][cH:15][c:16]2[c:17]1[OH:18].[Cu:28][C:29]#[N:30]>>[CH2:1]([CH2:2][CH2:3][CH3:4])[O:5][C:6](=[O:7])[c:8]1[n:9][c:10]([C:29]#[N:30])[c:11]2[cH:12][c:13]([O:19][c:20]3[cH:21][cH:22][c:23]([F:26])[cH:24][cH:25]3)[cH:14][cH:15][c:16]2[c:17]1[OH:18]Participants
3
Sources & evidence
- ORD record
- ord-ac34e18054964f1bac34ae7b3e2f38a4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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