HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → methyl (2R)-2-amino-3-phenylpropanoate;hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | D-Phenylalanine | HCID 71567 | — |
| Product | methyl (2R)-2-amino-3-phenylpropanoate;hydrochloride | HCID 11481330 | 97% |
Reaction Steps
(D)-Phenylalanine (25.0 g) was dissolved in 450 mL of methanol and 22 mL thionyl chloride were slowly added at −20° C. The mixture was refluxed for 1 h, followed by evaporation of the volatiles to give 31.2 g (97%) of the title compound as a white solid. M.p. 155-163° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06797710B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-16d8ddbb06a24471b0b4b9931700a15f |
| Source note | uspto-grants-2004_09 |