Proline benzyl ester hydrochloride → HCID 15386047, compound

HRID 1008591Notes

Reaction equation

HRID 1008591 reaction equation
[CH3:1][S:2]([NH:5][C@H:6]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:7]([OH:9])=O)(=[O:4])=[O:3].Cl.[CH2:18]([O:25][C:26](=[O:32])[C@@H:27]1[CH2:31][CH2:30][CH2:29][NH:28]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([O:25][C:26]([C@@H:27]1[CH2:31][CH2:30][CH2:29][N:28]1[C:7](=[O:9])[C@H:6]([NH:5][S:2]([CH3:1])(=[O:3])=[O:4])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:32])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 2733413Proline benzyl ester hydrochlorideHCID 22867972HCID 22867972, compound

Product 1

HCID 15386047HCID 15386047, compoundYield 76.5%

Procedure

reaction of 0.65 g of 2-(R)-methanesulfonylamino-3-phenyl-propionic acid and 0.66 g of (L)-proline benzyl ester hydrochloride using the procedure described for example xib yielded 0.88 g (75%) of the title compound as a yellow oil. (+)-APCI-MS: 431 (MH+).

Sources & evidence

ORD record
ord-8d6493a788d54aad8f9acb5d4b5ca118
Source dataset
uspto-grants-2004_09
Patent number
US06797710B2

Reaction notes

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