HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitromethane → 1-Benzhydryl-6-chloro-2-(2-nitro-vinyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | 1-benzhydryl-6-chloro-1H-indole-2-carbaldehyde | HCID 16116334 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-Benzhydryl-6-chloro-2-(2-nitro-vinyl)-1H-indole | HCID 67055421 | 48% |
Reaction Steps
A solution of 1-benzhydryl-6-chloro-1H-indole-2-carbaldehyde (0.5M, 1 equiv.) and NH4OAc (1 equiv.) in nitromethane was heated at 95° C. for 70 min. The mixture was diluted with EtOAc, washed with water, and dried. Evaporation of the volatiles, followed by trituration with ether/hexane produced 1-Benzhydryl-6-chloro-2-(2-nitro-vinyl)-1H-indole in 48% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06797708B2 |
| Source dataset | uspto-grants-2004_09 |
| ORD ID | ord-93af03b1895c440a9e59acf92b213804 |
| Source note | uspto-grants-2004_09 |