Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → 4-Acetoxy-2-hydroxy-benzoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methyl 2,4-Dihydroxybenzoate | HCID 16523 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 4-Acetoxy-2-hydroxy-benzoic acid methyl ester | HCID 57990217 | 23.4% |
반응 단계
2,4-Dihydroxy-benzoic acid methyl ester (11.76 g, 70 mmol) was dissolved in Et2O (175 mL). Then Et3N (10.78 mL, 77 mmol), Ac2O (7.28 mL, 77 mmol), and DMAP (catalytic amount) were added. The reaction solution was then stirred for one hour at room temperature. Then the reaction solution was concentrated by rotary evaporation and the resulting residue was purified with a silica gel column and dichloromethane as eluent. Obtained 3.44 g 4-Acetoxy-2-hydroxy-benzoic acid methyl ester in 23% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06797708B2 |
| 출처 데이터셋 | uspto-grants-2004_09 |
| ORD ID | ord-d83dc923efac41ac9e8561e3337560ca |
| 출처 메모 | uspto-grants-2004_09 |