HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1008741Generated: October 26, 2026
4,6-Dichloropyrimidine → 4-Chloro-6-(cis-2,6-dimethylpiperidino)pyrimidine
https://huagongshe.com/reaction/1008741
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | rel-(2R,6S)-2,6-Dimethylpiperidine | HCID 641768 | — |
| Product | 4-Chloro-6-(cis-2,6-dimethylpiperidino)pyrimidine | HCID 86607466 | 27.7% |
Reaction Steps
0.5 g of 4,6-dichloropyrimidine and 0.76 g of cis-2,6-dimethylpiperidine were mixed and stirred for 10 hours at 90° C. The reaction mixture was subjected to silica gel column chromatography to obtain 0.21 g of 4-chloro-6-(cis-2,6-dimethylpiperidino)pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07973028B2 |
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| Source dataset | uspto-grants-2011_07 |
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| ORD ID | ord-f413fb6950774ab1a56150f0767971bf |
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| Source note | uspto-grants-2011_07 |
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