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Benzaldehyde → Methyl 2-benzylideneaminohexanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 反応物 | Methyl norleucinate--hydrogen chloride (1/1) | HCID 14039064 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methyl 2-benzylideneaminohexanoate | HCID 23074255 | 100% |
反応手順
Triethylamine (8.67 g) (supplied from Wako Pure chemical Industries), 7.74 g of magnesium sulfate anhydrate and 4.55 g of benzaldehyde were added to a suspension of 7.79 g of methyl 2-aminohexanoate hydrochloride in 70 mL of dichloromethane, and stirred at room temperature overnight. The reaction suspension was filtrated, and the filtrate was concentrated. Then 280 mL of ether was added to the residue. The resulting suspension was filtrated and the filtrate was concentrated. Again 280 mL of ether was added to the residue, and the filtration and the concentration were repeated in the same manner, to yield 10.0 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07973030B2 |
| 出典データセット | uspto-grants-2011_07 |
| ORD ID | ord-00193568fc4a4a99800949f3fe36318f |
| 出典メモ | uspto-grants-2011_07 |