Hydroxylamine → HCID 11565825, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[(1E)-1-buten-3-ynylsulfonyl]-4-(2-pyridinyl)piperazine (30 mg; 0.11 mmol; 1.00 eq.) in THF (3 mL) was added an aq. solution of hydroxylamine (50%, 0.10 mL; 1.62 mmol; 15.0 eq.) and the resulting reaction mixture was stirred at 60° C. for 4 h. Evaporation of the solvents (rotavap gave an oil). Purification on silicagel (50/50 up to 70/30 AcOEt-c-Hex) a colorless oil (15 mg, 44% yield). LC/MS, M+ (ESI): 311.1, M−(ESI): 311.1, M− (ESI): 309.0.

Provenance & Evidence