Formic Acid → HCID 11588105, compound

Participants

Reaction Steps

Acetic anhydride (25 mg; 0.24 mmol; 5.0 eq.) was added to cold (0° C.) formic acid (111 mg; 2.42 mmol; 50.0 eq.). The mixture was stirred 1 h, then a 1 M solution of 1-{[2-(hydroxyamino)-3-butynyl]sulfonyl}-4-(2-pyridinyl)piperazine (15 mg; 0.05 mmol; 1.0 eq.) in THF was added. After 4 h, the solvents were evaporated and the crude product was purified on silicagel (80/20 EtOAc/c-Hex) to give the title compound (12) as a colorless oil (2.3 mg, 14% yield). LC/MS, M+(ESI): 339.2, M−(ESI): 337.1.

Provenance & Evidence