HRID1008942

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID59128585

未命名化合物

结构：CN1CC(c2ccc(N)c(C3=CCC(C)(C)CC3)c2)CN(C)C1=NC#N

HCID86615903

未命名化合物

结构：N#Cc1c[nH]c(C(=O)Nc2ccc(C3CC(=O)NC(=O)C3)cc2C2=CCCCC2)n1

HCID178510414

未命名化合物

PRODUCTS

生成物

结构：CN1CC(c2ccc(NC(=O)c3nc(C#N)cn3COCC[Si](C)(C)C)c(C3=CCC(C)(C)CC3)c2)CN(C)C1=NC#N

HCID86615905

未命名化合物

PROCEDURE

实验过程

5-[4-Amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-1,3-dimethyl-tetrahydro-pyrimidin-2-ylidene-cyanamide (as prepared in the previous step) was coupled to 4-cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid, potassium salt (as prepared in Example 1) as described in Example 1, step (1) to obtain the title compound: Mass spectrum (ESI, m/z): Calcd. for C32H44N8O2Si, 601.3 (M+H). found 601.3.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8f9bca2bc74d48388d89d9a8ad8e5f5b
来源数据集: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07973035B2
来源说明: uspto-grants-2011_07

反应 SMILES

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][N:12]([CH3:14])[C:11](=[N:15][C:16]#[N:17])[N:10]([CH3:18])[CH2:9]2)=[CH:4][C:3]=1[C:19]1[CH2:24][CH2:23][C:22]([CH3:26])([CH3:25])[CH2:21][CH:20]=1.[C:27]([C:29]1[N:30]=[C:31]([C:42](O)=[O:43])[N:32]([CH2:34][O:35][CH2:36][CH2:37][Si:38]([CH3:41])([CH3:40])[CH3:39])[CH:33]=1)#[N:28].C1(C2C=C(C3CC(=O)NC(=O)C3)C=CC=2NC(C2NC=C(C#N)N=2)=O)CCCCC=1>>[C:16]([N:15]=[C:11]1[N:12]([CH3:14])[CH2:13][CH:8]([C:5]2[CH:6]=[CH:7][C:2]([NH:1][C:42]([C:31]3[N:32]([CH2:34][O:35][CH2:36][CH2:37][Si:38]([CH3:41])([CH3:40])[CH3:39])[CH:33]=[C:29]([C:27]#[N:28])[N:30]=3)=[O:43])=[C:3]([C:19]3[CH2:24][CH2:23][C:22]([CH3:26])([CH3:25])[CH2:21][CH:20]=3)[CH:4]=2)[CH2:9][N:10]1[CH3:18])#[N:17]