反应详情

N-bromo succinimide (1.5 eq.) was added at 0° C. to a 0.1M solution of methyl 6-(2-fluorocyclohexyl)-4-(2-methoxy-2-oxoethyl)-4H-thieno[3,2-b]pyrrole-2-carboxylate in dry DCM, and the mixture was stirred for 1 h. After dilution with EtOAc, the organic layer was washed with aq. Na2S2O3-solution and brine, dried over Na2SO4 and concentrated i. vac. Yield: 100%. 1H-NMR (300 MHz, CDCl3, 300 K, δ) 7.58 (s, 1H), 4.88 (d, 1H, J 17.9), 4.79 (d, 1H, J 17.9), 4.64 (dtd, 1H, J 49.3, 10.6, 4.4), 3.88 (s, 3H), 3.78 (s, 3H), 2.94-2.83 (m, 1H), 2.28-2.24 (m, 1H), 1.99-1.33 (m, 7H); MS (ES+) m/z 432, 434 (M+H)+.

1. washAfter dilution with EtOAc, the organic layer was washed with aq. Na2S2O3-solution and brine
2. dry with materialdried over Na2SO4
3. concentrationconcentrated i