huagongshe.com
HRID1008999

反应详情

EQUATION

反应方程式

HRID 1008999 的结构方程式

REACTANTS

反应物

2
结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：COC(=O)c1sc2c(C3CCCCC3)c(-c3ccccc3OC[C@@H](CBr)NC(=O)OCc3ccccc3)[nH]c2c1C
HCID67298840

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1sc2c(C3CCCCC3)c3n(c2c1C)C[C@@H](NC(=O)OCc1ccccc1)COc1ccccc1-3
HCID67298705

未命名化合物

收率 45%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Methyl 5-{2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-bromopropyl)oxy]phenyl}-6-cyclohexyl-3-methyl-4H-thieno[3,2-b]pyrrole-2-carboxylate was dissolved in DMF (0.034M) and NaH (1.1 eq., 60% in mineral oil) was added. The mixture was left stirring at RT. After 30 min all volatiles were evaporated i. vac. The residual material was purified by chromatography (PE:EtOAc, 8.5:1.5). The product was obtained as a colourless solid (45%). MS (ES+) m/z 559 (M+H)+.

WORKUP

后处理

  1. waitThe mixture was left
  2. customAfter 30 min all volatiles were evaporated i
  3. customThe residual material was purified by chromatography (PE:EtOAc, 8.5:1.5)