Triethylamine → HCID 42635071, compound

Participants

Reaction Steps

To a suspension of 7-pyridin-4-yl-benzo[b]thiophene-2-sulfonic acid amide (0.10 g, 0.34 mmol) in acetonitrile (3 mL) were added triethylamine (0.11 mL, 0.8 mmol) and at 0-5° C. phenylchloroformate (0.065 g, 0.40 mmol). The mixture was stirred at rt for 2 h, and 5-bromo-thiazol-2-yl-amine (0.092 g, 0.50 mmol) was added. The reaction mixture was stirred at 55-60° C. for 3 h. After cooling down to rt, the solution was chromatographed over silica gel using dichloromethane/methanol as eluent to obtain the title compound (0.045 g) as a light brown solid. MS (ISN) m/e 492.8, 494.8 (M−H)−

Provenance & Evidence