Ammonia methanol → HCID 42633088, compound

HRID 1009018Notes

Reaction equation

HRID 1009018 reaction equation
[Br:1][C:2]1[S:6][C:5]([NH:7][C:8]([NH:10][S:11]([C:14]2[C:22]3[C:17](=[C:18]([O:23][CH2:24][C:25]([O:27]CC)=O)[CH:19]=[CH:20][CH:21]=3)[N:16]([CH3:30])[CH:15]=2)(=[O:13])=[O:12])=[O:9])=[N:4][CH:3]=1.[NH3:31].CO>>[Br:1][C:2]1[S:6][C:5]([NH:7][C:8]([NH:10][S:11]([C:14]2[C:22]3[C:17](=[C:18]([O:23][CH2:24][C:25]([NH2:31])=[O:27])[CH:19]=[CH:20][CH:21]=3)[N:16]([CH3:30])[CH:15]=2)(=[O:12])=[O:13])=[O:9])=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 21705897Ammonia methanolHCID 42633087HCID 42633087, compound

Product 1

HCID 42633088HCID 42633088, compound

Procedure

A solution of ethyl {[3-({[(5-bromo-1,3-thiazol-2-yl)carbamoyl]amino}sulfonyl)-1-methyl-1H-indol-7-yl]oxy}acetate (0.050 g, 0.09 mmol) in 7N ammonia/methanol, (5 mL) was heated at 40° C. for 5 h. The reaction mixture was concentrated to dryness and dried under high vacuum to obtain the title compound (0.040 g) as a grey amorphous solid. MS (ISN): m/e 486.4, 488.3 (M−H)−

Workup

  1. concentrationThe reaction mixture was concentrated to dryness
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-d23d4309dbbb4c8980ef2974ff18d50d
Source dataset
uspto-grants-2011_07
Patent number
US07973051B2

Reaction notes

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