反应详情

5-Bromo-4-methyl-thiazol-2-ylamine (0.5 g, 2.59 mmol) was dissolved in methanol abs. (10 mL). The solution was cooled with an ice-bath, then under stirring was added portionwise sodium methoxide (140 mg, 2.59 mmol) The black reaction mixture was stirred for 30 min. at rt then poured into a mixture of dichloromethane/water. The aqueous layer was extracted with two portions of dichloromethane. The combined, organic extracts were dried over magnesium sulfate, filtered and evaporated under reduced pressure to obtain the crude product which was used without further purification. MS (EI): m/e 144.1.

1. temperatureThe solution was cooled with an ice-bath
2. customThe black reaction mixture
3. stirringwas stirred for 30 min. at rt
4. extractionThe aqueous layer was extracted with two portions of dichloromethane
5. dry with materialorganic extracts were dried over magnesium sulfate
6. filtrationfiltered
7. customevaporated under reduced pressure