反应详情

温度

0 °C

The above prepared 4-ethyl-thiazol-2-ylamine (1.125 g, 8.77 mmol) was dissolved in 4.5 mL of 20% aq. sulfuric acid, cooled to 0° C., and treated with Br2 (0.494 mL, 1.1 eq.). After 10 Min., the reaction mixture was carefully poured onto crashed ice/Na2CO3, twofold extracted with ethyl acetate, washed with water, dried over sodium sulfate, and evaporated to dryness. Thereby, 1.306 g of the title compound was obtained as light brown viscous oil, sufficiently pure to be used for the next step.

1. addition, the reaction mixture was carefully poured
2. extractiontwofold extracted with ethyl acetate
3. washwashed with water
4. dry with materialdried over sodium sulfate
5. customevaporated to dryness