Ammonia → HCID 67304797, compound

Participants

Reaction Steps

To a solution of the above prepared 4-(2-methoxy-ethyl)-5-methyl-thiophene-2-sulfonyl chloride (4.59 g, 18 mmol) in DCM (18 mL) were added 25% aqueous NH3 (9 mL, ˜120 mmol) and the biphasic reaction mixture was vigorously stirred at rt for 3 h. After the addition of DCM (120 mL) the reaction mixture was washed with H2O (2×120 mL) and the aqueous layers were extracted with DCM (50 mL). The combined organic layers were dried (Na2SO4) and evaporated affording 5.0 g crude product as a yellow viscous oil which was purified by chromatography over silica with hexane-ethyl acetate 2:1 providing 3.62 g (85% GC 96.3%) yellow viscous oil. ESI-MS (m/z) 253 (M+NH4+, 100).

Provenance & Evidence