反应详情

4-Ethyl-thiazol-2-ylamine (0.960 g, 7.49 mmol) was dissolved in 17 mL of CH2Cl2 and 3.5 mL of acetic acid and treated at 0° C. with iodine monochloride (7.86 mL of 1M in CH2Cl2, 1.05 eq.) and kept at this temperature for 1 h. Pouring onto crashed ice/Na2CO3, twofold extraction with ethyl acetate, washing with water and brine, drying over sodium sulfate, and evaporation to dryness afforded 1.67 g of the title compound as almost black viscous oil, sufficiently pure to be used for the next step.

1. additionPouring
2. extractionice/Na2CO3, twofold extraction with ethyl acetate
3. washwashing with water and brine
4. dry with materialdrying over sodium sulfate, and evaporation to dryness