Chlorotrimethylsilane → Trimethyl-(2-methyl-1-methylene-propoxy)-silane

Participants

Reaction Steps

To freshly prepared LDA-solution in THF/hexane (1.05 eq.) was added slowly at −78° C. chloro-trimethyl-silane 7.59 mL, 60 mmol, 1.2 eq.), followed by 3-methyl-butan-2-one 5.32 mL, 50 mmol). The reaction vessel was kept for 30 Min. at −78° C. and then allowed to reach RT. The reaction mixture was diluted with 200 mL of pentane and filtered. All volatile solvents were then evaporated from the filtrate and the residue distilled in vacuo (50 mbar, bp. 40-45° C.) to give 4.38 g of regioisomerically pure title compound as colorless liquid.

Provenance & Evidence