Imidazole → HCID 59347037, compound

HRID 1009121Notes

Reaction equation

HRID 1009121 reaction equation
[OH:1][CH2:2][C@H:3]1[O:7][C:6]([CH3:9])([CH3:8])[N:5]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C@H:4]1[CH2:17][C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1.[CH3:24]C([Si](Cl)(C)C)(C)C.N1C=CN=C1>>[OH:1][CH2:2][C@H:3]1[O:7][C:6]([CH3:8])([CH3:9])[N:5]([C:10]([O:12][C:13]([CH3:15])([CH3:16])[CH3:14])=[O:11])[C@H:4]1[CH2:17][C:18]1[CH:19]=[CH:20][N:21]=[C:22]([CH3:24])[CH:23]=1

Participants

4

Reactant 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 59347035HCID 59347035, compound

Product 1

HCID 59347037HCID 59347037, compound

Procedure

The title compound was synthesized in manner analogous to that described in Example 472, using (4S,5S)-tert-butyl 5-(hydroxymethyl)-2,2-dimethyl-4-(pyridin-4-ylmethyl)oxazolidine-3-carboxylate in the presence of TBSCl and imidazole, and was used without further purification.

Workup

  1. customwas used without further purification

Sources & evidence

ORD record
ord-480d0d5eda0648fc986620d7439b0dee
Source dataset
uspto-grants-2011_07
Patent number
US07973047B2

Reaction notes

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