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温度

0 °C

NaH (60% by weight in mineral oil) (0.672 g, 16.8 mmol) was added carefully to trifluoroethanol (20.0 ml, 276 mmol) cooled at 0° C. and then stirred at RT for 30 minutes. The resulting solution is added to (4S,5S)-tert-butyl 4-((2-chloropyridin-4-yl)methyl)-5-(hydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate (0.400 g, 1.12 mmol) dissolved in 10 mL of NMP and the resulting solution was microwaved for 30 minutes fixed at 180° C. The reaction was diluted with EtOAc and washed repeatedly with water. The combined aqueous layers were back extracted with EtOAc and the combined organic layers were washed with water, brine, dried over sodium sulfate and concentrated. The product was purified by silica gel chromatography (2:1 to 1:1 Hexanes/EtOAc) to afford the title compound. MS m/z: 421.3 (100%, M+1).

1. customthe resulting solution was microwaved for 30 minutes
2. customfixed at 180° C
3. washwashed repeatedly with water
4. extractionThe combined aqueous layers were back extracted with EtOAc
5. washthe combined organic layers were washed with water, brine
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated
8. customThe product was purified by silica gel chromatography (2:1 to 1:1 Hexanes/EtOAc)