HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichlorothiazole → (S)-methyl 2-(tert-butoxycarbonyl)-3-(4-chlorothiazol-2-yl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichlorothiazole | HCID 12333155 | — |
| Reactant | (R)-methyl2-(tert-butoxycarbonyl)-3-iodopropanoate | HCID 86614124 | — |
| Product | (S)-methyl 2-(tert-butoxycarbonyl)-3-(4-chlorothiazol-2-yl)propanoate | HCID 67305732 | — |
Reaction Steps
The title compound was synthesized in a manner analogous to that described Example 475, using (R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate and 2,4-dichlorothiazole (prepared according to Reynaud, Pierre; Robba, Max; Moreau, Robert C; New synthesis of the thiazole ring; Bulletin de la Societe Chimique de France (1962), 1735-8). MS m/z: 321 (23%, M+1), 265.0 (100%, M−55.1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07973047B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-d618dc6f90b7403f807a6bbdd51653c7 |
| Source note | uspto-grants-2011_07 |