4-Chloro-2-(trifluoromethyl)pyrimidine → HCID 67271000, compound

HRID 1009131Notes

Reaction equation

HRID 1009131 reaction equation
[C:1]([O:5][C:6]([C@H:8]([CH2:13]I)[C:9]([O:11][CH3:12])=[O:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:16]1[CH:21]=[CH:20][N:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[N:17]=1>>[C:1]([O:5][C:6]([C@@H:8]([CH2:13][C:16]1[CH:21]=[CH:20][N:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[N:17]=1)[C:9]([O:11][CH3:12])=[O:10])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 152943694-Chloro-2-(trifluoromethyl)pyrimidineHCID 86614124(R)-methyl2-(tert-butoxycarbonyl)-3-iodopropanoate

Product 1

HCID 67271000HCID 67271000, compound

Procedure

The title compound was synthesized in a manner analogous to that described Example 475, using (R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate and 4-chloro-2-(trifluoromethyl)pyrimidine.

Sources & evidence

ORD record
ord-05dfd88bdfad402db823386a962415d2
Source dataset
uspto-grants-2011_07
Patent number
US07973047B2

Reaction notes

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