HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-(triisopropylsilyl)thiazole → (S)-methyl 2-(tert-butoxycarbonyl)-3-(2-(triisopropylsilyl)thiazol-5-yl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-(triisopropylsilyl)thiazole | HCID 59601131 | — |
| Reactant | (R)-methyl2-(tert-butoxycarbonyl)-3-iodopropanoate | HCID 86614124 | — |
| Product | (S)-methyl 2-(tert-butoxycarbonyl)-3-(2-(triisopropylsilyl)thiazol-5-yl)propanoate | HCID 67270410 | — |
Reaction Steps
The title compound was synthesized in a manner analogous to that described Example 475, using (R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate and 5-bromo-2-(triisopropylsilyl)thiazole (prepared according to Stangeland, Eric L.; Sammakia, Tarek, Use of Thiazoles in the Halogen Dance Reaction: Application to the Total Synthesis of WS75624 B, Journal of Organic Chemistry (2004), 69(7), 2381-2385.). MS m/z: 443.3 (100%, M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07973047B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-baccf44de2094154aea9a4ef0660e470 |
| Source note | uspto-grants-2011_07 |