HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-4-fluorobenzyl Bromide → (S)-N-((2S,3S)-1-(3-Bromo-4-fluorophenyl)-3,4-bis(tert-butyldimethylsilyloxy)butan-2-yl)-2-methylpropane-2-sulfinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-4-fluorobenzyl Bromide | HCID 12922710 | — |
| Reactant | (NE,S)-N-[(2S)-2,3-bis[[tert-butyl(dimethyl)silyl]oxy]propylidene]-2-methylpropane-2-sulfinamide | HCID 44239381 | — |
| Product | (S)-N-((2S,3S)-1-(3-Bromo-4-fluorophenyl)-3,4-bis(tert-butyldimethylsilyloxy)butan-2-yl)-2-methylpropane-2-sulfinamide | HCID 67304989 | — |
Reaction Steps
The title compound was prepared from (S,E)-N—((S)-2,3-bis(tert-butyldimethylsilyloxy)propylidene)-2-methylpropane-2-sulfinamide and 2-bromo-4-(bromomethyl)-1-fluorobenzene using a method analogous to that described in Examples 509 and 510.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07973047B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-d3d0c7968b0c4646aaa296fdacfd607a |
| Source note | uspto-grants-2011_07 |