Dimethylformamide → HCID 16046253, compound

Participants

Reaction Steps

A solution of 4-benzyloxy-1H-pyridone (300 mg, 1.49 mmol) and NaH (60 mg, 1.49 mmol) in solvent of DMF was stirred for 30 min followed by adding 2-chlorobenzyl chloride (240 mg, 1.49 mmol) further stirring for 30 min at room temperature. The resulting solution was worked up with Water and dichloromethane and purified by column chromatography (ethyl acetate/hexane, 1:1) to obtain the titled compound (320 mg, 67%).

Provenance & Evidence