反应详情

A mixture of 500 mg of 4-(isobutylthio)pyridine-N-oxide, 5 ml of acetic anhydride was heated at reflux for 10 hours. The mixture was cooled, then added MeOH and 3N NaOH was added dropwise at pH 9˜11 and stirred. After 1 hour solution was evaporated and 3N HCl was added dropwise at pH6.5˜7.5, extracted with ethyl acetate and subjected to silica gel column chromatography (hexane/ethyl acetate) to obtain the compound (90 mg).

1. temperaturewas heated
2. temperatureat reflux for 10 hours
3. temperatureThe mixture was cooled
4. customAfter 1 hour solution was evaporated
5. addition3N HCl was added dropwise at pH6.5˜7.5
6. extractionextracted with ethyl acetate