HuagongsheHuagongshe Chemistry Print Report · For research reference only
alpha-Chloro-2-methyl-3-nitrotoluene → 4-(isobutylthio)-1-(2-methyl-3-nitrobenzyl)pyridine-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | alpha-Chloro-2-methyl-3-nitrotoluene | HCID 108947 | — |
| Reactant | 4-Isobutylthio-2-pyridone | HCID 14072675 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(isobutylthio)-1-(2-methyl-3-nitrobenzyl)pyridine-2(1H)-one | HCID 67305200 | 49.6% |
Reaction Steps
A mixture of 100 mg of 4-(isobutylthio)pyridine-2(1H)-one, 2 ml of DMF, 65 mg of t-BuOK was stirred at room temperature and 105 mg of 2-methyl-3-nitrobenzyl chloride was added. After 3 hour, the resulting solution was evaporated, extracted with dichloromethane and subjected to silica gel column chromatography (hexane/ethyl acetate) to obtain the compound (90 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07973060B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-035691ddf2b44c0e80f2cc66877af594 |
| Source note | uspto-grants-2011_07 |