HCID 74326946, compound → HCID 24827765, compound

Participants

Reaction Steps

A mixture of compound 12 (20 mg) and Pd—C (40 mg) in methanol (5 mL) was stirred under hydrogen (50 psi) overnight, filtered, and concentrated to dryness under vacuum. The residue was purified by silica gel flash chromatography and re-crystallized with ethyl acetate-hexane (1:8), giving compound 20 (14 mg). 1H NMR (250 MHz, CDCl3) 0.81 (s, 3H), 1.16-1.59 (m, 10H), 3.13 (dd, 1H, J=9.3 Hz, 8.7 Hz), 3.45 (s, 2H), 3.51 (dd, 1H, J=9.3 Hz, 3.6 Hz), 4.44 (dd, 1H, J=3.6 Hz, 8.7 Hz), 5.53 (s, 1H), 6.92 (d, 1H, J=8.40 Hz), 7.33 (d, 1H, J=8.40 Hz), 7.39 (s, 1H), HRMS exact mass of (M+Na)+, 422.1170 amu; observed mass of (M+Na)+, 422.1173 amu.

Provenance & Evidence