HCID 11957759, compound → HCID 11965220, compound

Participants

Reaction Steps

A solution of 3,3-bis(phenylcarbamoyloxymethyl)-5-methylthiochroman-4-one (190 mg, 0.4 mmol) in MeOH (5 ml) was admixed with a solution of sodium metaperiodate (92 mg, 0.43 mmol) in water (1 ml), and stirred at RT for 72 h. The reaction mixture was diluted with water (50 ml) and extracted with EtOAc (3×30 ml), the combined organic phases were dried over sodium sulfate and the solvent was removed under reduced pressure. After column chromatography purification of the residue (silica gel, 1:1 cyclohexane/EtOAc), the desired product was obtained as a white solid (190 mg, 89% of theory, m.p. 76-82° C.).

Provenance & Evidence