HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethoxy-2,2-difluoroethanol → HCID 178445928, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethoxy-2,2-difluoroethanol | HCID 2758246 | — |
| Reactant | {[(2S)-2-amino-4-methylpentyl]oxy}(tert-butyl)dimethylsilane | HCID 11345273 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 178445928 | HCID 178445928 | — |
Reaction Steps
A mixture of (2S)-1-{[tert-butyl(dimethyl)silyl]oxy}-4-methylpentan-2-amine (8.5 g, 36.8 mmol) and difluoroacetaldehyde ethyl hemiacetal (5.0 g, 39.7 mmol) in benzene was refluxed with a Dean-stark trap overnight. Solvent was removed in vacuo. The residue was passed through a short silica column and eluted with hexanes:EtOAc (10:1) to give the title compound as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07973037B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-97b2e13d63164da98d157382c976e8cb |
| Source note | uspto-grants-2011_07 |