HCID 57446951, compound → HCID 13675226, compound

HRID 1009271Notes

Reaction equation

HRID 1009271 reaction equation
[F:1][C:2]([F:21])([F:20])[C@@H:3]([CH3:19])[CH2:4][C@H:5]([NH:8]C(=O)OCC1C=CC=CC=1)[CH2:6][OH:7]>CCO.[Pd]>[NH2:8][C@@H:5]([CH2:4][C@H:3]([CH3:19])[C:2]([F:1])([F:20])[F:21])[CH2:6][OH:7]

Participants

4

Reactant 1

HCID 57446951HCID 57446951, compound

Product 1

HCID 13675226HCID 13675226, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The above alcohol was dissolved in EtOH (150 mL) and 10% Pd/C (−500 mg) was added. The mixture was stirred under a H2 atmosphere (ballon) overnight. The catalyst was filtered off through celite and the filtrate was concentrated to give the title compound as a colorless oil.

Workup

  1. filtrationThe catalyst was filtered off through celite
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-902cb048c63d45e0adb794c311421819
Source dataset
uspto-grants-2011_07
Patent number
US07973037B2

Reaction notes

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