Hydrazine → 2-(4-Fluorophenyl)-4-hydroxy-2-methoxybutyric acid hydrazide

HRID 1009407Notes

Reaction equation

HRID 1009407 reaction equation
[NH2:1][NH2:2].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2([O:16][CH3:17])[CH2:14][CH2:13][O:12][C:11]2=[O:15])=[CH:6][CH:5]=1>C(O)C>[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([O:16][CH3:17])([CH2:14][CH2:13][OH:12])[C:11]([NH:1][NH2:2])=[O:15])=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 670671553-(4-Fluorophenyl)-3-methoxydihydrofuran-2-one

Product 1

HCID 670673452-(4-Fluorophenyl)-4-hydroxy-2-methoxybutyric acid hydrazideYield 96.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of hydrazine (29 mg) in ethanol (0.5 mL) was added to a solution of 3-(4-fluorophenyl)-3-methoxydihydrofuran-2-one (37 mg) in ethanol (1.2 mL), and the reaction solution was stirred at room temperature for 2.5 hours. The reaction solution was concentrated under reduced pressure to obtain 41 mg of the title compound. The property values of the compound are as follows.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3236e39468244beab41279eed019e212
Source dataset
uspto-grants-2011_07
Patent number
US07973033B2

Reaction notes

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