Water → HCID 58009565, compound

Participants

Reaction Steps

652 mg of 4-{[(3-chloro-2-methylphenyl)amino]sulfonyl}benzoic acid was dissolved in 10.0 mL of THF, and 6.00 mL of a 1 M borane-THF complex was added thereto under an argon atmosphere, followed by stirring at room temperature for 4 hours. To the reaction liquid was added 1.00 mL of a mixed solution of water-acetic acid (1:1) and added water, followed by extraction with ethyl acetate. The organic layer was washed with an aqueous saturated sodium hydrogen carbonate solution and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to obtain 467 mg of N-(3-chloro-2-methylphenyl)-4-(hydroxymethyl)benzenesulfonamide.

Provenance & Evidence