Hydrochloric Acid → HCID 24883170, compound

Participants

Reaction Steps

308 mg of methyl 4-[({N-(3-chloro-2-methylphenyl)-N-[(4-methylphenyl)sulfonyl]glycyl}amino)methyl]benzoate was dissolved in 5.00 mL of methanol and 2.00 mL of THF, and 2.40 mL of a 1 M aqueous sodium hydroxide solution was added thereto, followed by stirring at room temperature overnight. Then, to the reaction liquid was added 3.00 mL of THF, followed by stirring at 60° C. for 4 hours. The reaction liquid was ice-cooled, acidified by addition of 2.60 mL of 1 M hydrochloric acid, and then extracted with a mixed solvent of chloroform/methanol (5/1), and the organic layer was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (chloroform:methanol=100:0 to 90:10) to obtain 601 mg of 4-[({N-(3-chloro-2-methylphenyl)-N-[(4-methylphenyl)sulfonyl]glycyl}amino)methyl]benzoic acid.

Provenance & Evidence