HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methane → 1-(4-Fluorophenyl)-1H-imidazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | HCID 17390092 | HCID 17390092 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(4-Fluorophenyl)-1H-imidazole-4-carboxylic acid | HCID 17390048 | — |
Reaction Steps
Crude 1-(4-fluoro-phenyl)-1H-imidazole-4-carboxylic acid ethyl ester is dissolved in dioxane and sodium hydroxide solution. The reaction mixture is refluxed for about 2 h. Charcoal is added and reflux is continued. The desired compound 1-(4-fluoro-phenyl)-1H-imidazole-4-carboxylic acid is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07973165B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-8d02e3bfdb9145f59f37d1a4d48f2a77 |
| Source note | uspto-grants-2011_07 |