HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → [1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | 4-(tert-butyl-dimethyl-silanyloxymethyl)-1-(4-fluoro-phenyl)-2-methyl-1H-imidazole | HCID 131726173 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | [1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol | HCID 67303957 | — |
Reaction Steps
4-(tert-Butyl-dimethyl-silanyloxymethyl)-1-(4-fluoro-phenyl)-2-methyl-1H-imidazole is dissolved in THF. Tetrabutyl ammoniumfluoride in THF is added and the reaction mixture is stirred at room temperature overnight. The desired compound [1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07973165B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-bb06766c957944598b75eb7352a0460f |
| Source note | uspto-grants-2011_07 |