反应详情

温度

-5 °C

2,4-Dinitrobenzenesulphonyl chloride (3.1 g) was added dropwise to a stirred solution of 4-amino-1-methylpyrazole (2.55 g) in methylene chloride (50 ml) that had been cooled to −5° C. The resultant mixture was stirred at this temperature for 5 minutes. The mixture was washed in turn with water, a 5% aqueous ammonium chloride solution, a saturated aqueous sodium bicarbonate solution and brine. The organic phase was dried over magnesium sulphate and filtered. There was thus obtained a solution of N-(1-methylpyrazol-4-yl)-2,4-dinitrobenzenesulphonamide; Mass Spectrum: M+H+ 328.

1. washThe mixture was washed in turn with water
2. dry with materialThe organic phase was dried over magnesium sulphate
3. filtrationfiltered