Trifluoroacetic acid → HCID 178486807, compound

Participants

Reaction Steps

A mixture of N-[3-(N-tert-butoxycarbonylamino)-1-(3,4-dimethoxybenzyl)pyrazol-5-yl]-2-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]acetamide (0.2 g) and trifluoroacetic acid (5 ml) was stirred at ambient temperature for 2 hours. The resultant mixture was evaporated. The residue was purified by column chromatography on silica using a solvent gradient from 49:1 to 9:1 of methylene chloride and a 3M methanolic ammonia solution as eluent. There was thus obtained the title compound (0.045 g); 1H NMR: (DMSOd6) 3.63 (s, 2H), 3.93 (s, 3H), 3.95 (s, 3H), 5.05 (br s, 2H), 5.58 (s, 1H), 6.5 (d, 1H), 7.23 (d, 2H), 7.41 (s, 1H), 7.45 (d, 2H), 7.51 (s, 1H), 8.5 (d, 1H), 10.35 (br s, 1H); Mass Spectrum: M+H+ 420.

Provenance & Evidence